I3A - Instituto de Investigación en Ingeniería de Aragón

Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface

Main reseacher: Esther Pueyo
MODELAGE proposes a multi-scale,multi-factorial research that is expected to make an important step in the characterization of human heart aging at both the population and individual levels.
MODELAGE will work on an integrative methodological framework in which in silico modeling will be combined with in vitro cell and tissue analysis and in vivo electrocardiographic evaluation to investigate how cardiac aging manifests at a range of scales, from cell to body surface, and how electrical, structural and autonomic alterations contribute to such manifestations in humans.
By investigating the mechanisms underlying inter-individual differences in cardiac dynamics, MODELAGE will set links to arrhythmia susceptibility and will propose novel non-invasive markers to identify high-risk senescent individuals for which preventive anti-arrhythmic treatment
should be considered.
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